Jane A. Knappenberger

Genentech, Inc.
1 DNA Way  MS 62
South San Francisco, CA 94080
email: jknappen@gene.com

Current Position

Graduate Education

The Pennsylvania State University
2001–2006

Awards:

  • Roberts Graduate Fellowship, 2001–2003
  • Travel Award, The Pennsylvania State University Center for Biomolecular Structure & Function and NSF-RTG, 2001.

Undergraduate Education

Immaculata College
Fall 1997–Fall 2000
B.A. Chemistry, B.A. Mathematics, Summa Cum Laude
Honors Program

Awards

  • The Wendall P. MacIntosh Medal for Chemistry
  • The Anderson Medal for Mathematics
  • American Chemical Society, Philadelphia Section Annual Award, 2001
  • American Chemical Society, Polymer Education Committee Award for Outstanding Performance in Organic Chemistry, 1999
  • Who's Who Among College Students in American Colleges and Universities
  • Pennsylvania Athletic Conference All Conference Academic Team
  • Immaculata College Presidential Scholarship

Research Experience

July 2001-May 2006
The Pennsylvania State University
Advisor: Juliette T. J. Lecomte
Characterization of a chimeric protein consisting of the heme binding region of cytochrome b5 placed on the E subunit of photosystem I (PsaE), investigating autonomy of the b5 binding region and loop entropy effects.

January 2001-June 2001
The Pennsylvania State University
Advisor: C. Robert Matthews
Thermodynamic and kinetic characterization of the folding of the dimerization domain of the yeast transcriptional factor GCN4, looking at the effects of charged residues and a buried polar residue.

May 2000-August 2000
The Pennsylvania State University
Advisor: C. Robert Matthews
Paper title: Determining the Role of the Buried Asparagine Residue in the Folding and Function of the Yeast Transcriptional Factor GCN4.

August 1999-May 2000
Independent Study funded by NIH through Immaculata College's Office of Sponsored Research
Immaculata College
Advisor: Kathryn A. Lysko
Paper Title: Analysis of Chester County Well Water

May 1999-August 1999
NSF-REU Program
Bowling Green State University
Advisor: John R. Cable
Paper Title: Assignment of the Methyl Rotor Torsion Peaks in the Electronic Spectrom uf Acetanilide and Construction of a Torsional Potential Energy Function.

Teaching Experience

August 2001-December 2001
The Pennsylvania State University
Teaching Assistant
Principles of Chemistry

Publications

  1. Knappenberger, J.A., Smith, J.E., Thorpe, S.H., Zitzewitz, J.A., and Matthews, C.R. (2002) A Buried Polar Residue in the Hydrophobic Interface of the Coiled-coil Peptide, GCN4-p1, Plays a Thermodynamic, not a Kinetic Role in Folding. Journal of Molecular Biology 321:1-6.
  2. Knappenberger, J.A., Kraemer-Pecore, C.M., and Lecomte, J.T.J.(2004) Insertion of the Cytochrome b5 Heme-binding Loop into an SH3 Domain. Effects on Structure and Stability, and Clues about the Cytochrome’s Architecture. Protein Science, 13:2899–2908.
  3. Knappenberger, J.A., Kuriakose, S.A., Vu, B.C., Nothnagel, H.J., Vuletich, D.A., and Lecomte, J.T.J. Proximal Influences in Two-on-Two Globins: Effect of the Ala69Ser Replacement on Synechocystis sp. PCC 6803 Hemoglobin.Biochemistry 45:11401–11413.
  4. Knappenberger, J.A., and Lecomte, J.T.J. (2007) Loop Anchor Modification Causes the Population of an Alternative Native State in an SH3-like Domain. Protein Science, in press.