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Scott A. Showalter

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Center for RNA Molecular Biology

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Publications

Many of these publications can be viewed using the links below. These links are provided for informational purposes only. Please visit the appropriate publisher's website to print the complete articles. Undergraduate coauthors are underlined in the citations.
  1. Kumar, S., Showalter, S.A., & Noid, W.G. (2013) "Native-Based Simulations of the Binding Interaction Between RAP74 and the Disordered FCP1 Peptide." J. Phys. Chem. B, 117, 3074-3085.
  2. Quarles, K.A., Sahu, D., Havens, M.A., Forsyth, E.R., Wostenberg, C., Hastings, M.L., & Showalter, S.A. (2013) "Ensemble Analysis of Primary MicroRNA Structure Reveals an Extensive Capacity to Deform near the Drosha Cleavage Site." Biochemistry, 52, 795-807.
  3. Wostenberg, C., Lary, J.W., Sahu, D., Acevedo, R., Quarles, K.A., Cole, J.L., & Showalter, S.A. (2012) “The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs.” PLoS One, 7, e51829.
  4. Myers, C.P., Sun, S., Showalter, S.A., Miller, J.R., & Williams, M.E. (2012) “NMR Investigations of the Solution Structures of Ru-Zn Complexes Tethered by Oligo(aminoethylglycine) chains.” Polyhedron, 40, 118-124.
  5. Lawrence, C.W., & Showalter, S.A. (2012) “Carbon-Detected 15N NMR Spin Relaxation of an Intrinsically Disordered Protein: FCP1 Dynamics Unbound and in Complex with RAP74.” J. Phys. Chem. Lett., 3, 1409-1413.
  6. Wostenberg, C., Kumar, S., Noid, W.G., & Showalter, S.A. (2011) "Atomistic Simulations Reveal Structural Disorder in the RAP74-FCP1 Complex." J. Phys. Chem. B, 115, 13731-13739.
  7. Lawrence, C.W., Bonny, A., & Showalter, S.A. (2011) "The Disordered C-Terminus of the RNA Polymerase II Phosphatase FCP1 is Partially Helical in the Unbound State." Biochem. Biophys. Res. Comm., 410, 461-465.
  8. Wostenberg, C., Quarles, K.A., & Showalter, S.A. (2010) "Dynamic Origins of Differential RNA Binding Function in Two dsRBDs from the miRNA 'Microprocessor' Complex." Biochemistry, 49, 10728-10736.
  9. Wostenberg, C. & Showalter, S.A. (2010) “MD Simulations of the dsRBP DGCR8 Reveal Correlated Motions that may Facilitate pri-miRNA Binding.” Biophys. J., 99, 248-256.
  10. O'Hare, B., Benesi, A.J., & Showalter, S.A. (2009) "Incorporating 1H chemical shift determination into 13C-detected spectroscopy of intrinsically disordered proteins in solution." J. Mag. Reson., 200, 354-358.
  11. Showalter, S.A. (2009) “NMR Assignment of the Intrinsically Disordered C-terminal Region of Homo sapiens FCP1 in the Unbound State.” Biomol. NMR Assign., 3, 179-181.
  12. Levine, L.A., Kirin, S.I., Myers, C.P., Showalter, S.A., & Williams, M.E. (2009) “Heterometallic Ferrocene-Rhenium Complexes Linked by an Aminoethylglycine Scaffold.” Eur. J. Inorg. Chem., 2009, 613-621.

     

    Non-Penn State Papers

  13. Li, D.-W., Showalter, S.A., & Brüschweiler, R. (2010) "Entropy Localization in Proteins." J. Phys. Chem. B, 114, 16036-16044.
  14. Markwick, P.R.L., Showalter, S.A., Bouvignies, G., Brüschweiler, R., & Blackledge, M. (2009) “Structural Dynamics of Protein Backbone φ Angles: Extended Molecular Dynamics Simulations versus Experimental 3J Scalar Couplings.” J. Biomol. NMR.,45, 17-21.
  15. Salmon, L., Bouvignies, G., Markwick, P., Lakomek, N., Showalter, S., Li, D.-W., Walter, K., Griesinger, C., Brüschweiler, R., & Blackledge, M. (2009) “Protein Conformational Flexibility from Structure-Free Analysis of NMR Dipolar Couplings: Quantitative and Absolute Determination of Backbone Motion in Ubiquitin.” Angew. Chem. Int. Ed., 48, 4154-4157.
  16. Showalter, S.A., Bruschweiler-Li, L., Johnson, E., Zhang, F., & Brüschweiler, R. (2008) “Quantitative Lid Dynamics of MDM2 Reveals Differential  Ligand Binding Modes of the p53-Binding Cleft.” J. Am. Chem. Soc., 130, 6472-6478.
  17. Johnson, E., Showalter, S.A., & Brüschweiler, R. (2008) “A Multifaceted Approach to the Interpretation of NMR Order Parameters: A Case Study of a Dynamic α-Helix.” J. Phys. Chem. B, 112, 6203-6210.
  18. Johnson, E., Bruschweiler-Li, L., Showalter, S.A., Vuister, G., Zhang, F., & Brüschweiler, R. (2008) “Structure and Dynamics of Ca2+-Binding Domain 1 of the Na+/Ca2+ Exchanger In the Presence and in the Absence of Ca2+.“ J. Mol. Biol., 377, 945-955.
  19. Showalter, S.A., Johnson, E., Rance, M., & Brüschweiler, R. (2007) “Toward Quantitative Interpretation of Methyl-Side Chain Dynamics by Molecular Dynamics Simulations.” J. Am. Chem. Soc., 129, 14146-14147.
  20. Showalter, S.A., & Brüschweiler, R. (2007) “Quantitative Molecular Ensemble Interpretation of NMR Dipolar Couplings without Restraints.” J. Am. Chem. Soc., 129, 4158-4159.
  21. Showalter, S.A., & Brüschweiler, R. (2007) “Validation of Molecular Dynamics Simulations of Biomolecules Using NMR Spin Relaxation as Benchmarks:  Application to the AMBER99SB Force Field.” J. Chem. Theory Comput., 3, 961-975.
  22. Showalter, S.A., & Hall, K.B. (2005) “Correlated Motions in the U1A snRNA Stem/Loop 2:U1A RBD1 Complex.” Biophys. J., 89, 2046-2058.
  23. Showalter, S.A., Baker, N.A., Tang, C., & Hall, K.B. (2005) “Iron Responsive Element RNA Flexibility Described by NMR and Isotropic Reorientational Eigenmode Dynamics.” J. Biomol. NMR. 32, 179-193.
  24. Showalter, S. A., & Hall, K.B. (2005) “Isotropic Reorientational Eigenmode Dynamics Compliments NMR Relaxation Measurements for RNA.” Methods Enzymol. 394, 465.
  25. Showalter, S.A., & Hall, K.B. (2004) “Altering the RNA-binding mode of the U1A RBD1 Protein.” J. Mol. Biol. 335, 465-480.
  26. Showalter, S.A., & Hall, K.B. (2002)  “A Functional Role for Correlated Motion in the N-Terminal RNA Binding Domain of Human U1A Protein.” J. Mol. Biol. 322, 533-542.