Single Molecule Biophysics @ Penn State
: Lee Research group

 

Welcome to the Lee group in the Department of Chemistry at Penn State. We probe structural and positional dynamics of biomolecules and complexes at a single molecule level in order to understand how they function in cells. We currently study the effects of chromatin modifications on nucleosome dynamics and the mechanisms of DNA replication. Shown below is an experimental setup that we employed to study the spontaneous DNA opening motion at the nucleosome termini (Nucleic Acids Res 2015).

Experimental and instrumental setups

to study spontaneous DNA opening motion

at the nucleosome termini (NAR 2015).