Single Molecule Biophysics @ Penn State
: Lee Research group


Welcome to the Lee group in the Department of Chemistry at the Pennsylvania State University. We monitor structural and positional dynamics of single biomolecules in order to understand how they function in cells. We currently study effects of chromatin modifications on nucleosomal dynamics, the mechanism of translation by the ribosome, and the mechanism of DNA replication. Depicted above are setups we used to study structural dynamics of nucleosomal DNA and positioning dynamics of tRNA inside the ribosome. The dynamics were proposed to be critical in their functions.

Systems used to study
(A) Structural dynamics of DNA wrapped around a histone core (JACS 2010) and
(B) Positional dynamics of tRNA inside the ribosome (Biophys. J. 2010)