Recent Publications

(1) "Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by Chiral Titanate Complexes with a Tetradentate Ligand" Zhang, X. and Guo, C. Tetrahedron Letters 1995, 36, 4947-4950.

(2) "Synthesis of (1R, 1R')-2,6-Bis[1-(diphenylphosphino)ethyl]pyridine and its Application in Asymmetric Transfer Hydrogenation" Jiang, Q., Plew, D. V., Murtuza, S. and Zhang, X. Tetrahedron Letters 1996, 37, 797-800.

(3) "Asymmetric Allylic Alkylation Catalyzed by Palladium Complexes with New Chiral Ligands" Zhu, G., Terry, M. and Zhang, X. Tetrahedron Letters 1996, 37, 4475-4478.

(4) "Syntheses of Novel Chiral Monophosphines, 2,5-Dialkyl-7-phenyl-7-phosphabicyclo-[2.2.1]heptanes, and Their Application in Highly Enantioselective Pd-Catalyzed Allylic Alkylations" Chen, Z., Jiang, Q., Zhu, G., Xiao, D., Cao, P., Guo, C. and Zhang, X. J. Org. Chem. 1997, 62, 4521-4523.

(5) "Enantioselective Addition of Diethylzinc to Benzaldehyde Catalyzed by Chiral Titanate Complexes with Helical Ligands" Guo, C., Qiu, J. and Zhang, X. Tetrahedron 1997, 53, 4145-4158.

(6) "Highly Effective NPN-type Tridentate Ligands for Asymmetric Transfer Hydrogenation of Ketones" Jiang, Y., Jiang, Q., Zhu, G. and Zhang, X. Tetrahedron Letters 1997, 38, 215-218.

(7) "New Chiral Ligands for Catalytic Asymmetric Transfer Hydrogenation of Ketones" Jiang, Y., Jiang, Q., Zhu, G. and Zhang, X. Tetrahedron Letters 1997, 38, 6565-6568.

(8) "Asymmetric Allylic Alkylation Catalyzed by Palladium Complexes with a New Chiral Bisphosphine Ligand" Longmire, J. M., Zhu, G. and Zhang, X. Tetrahedron Letters 1997, 38, 375-378.

(9) "Synthesis of Chiral Phosphine Ligands with Aromatic Backbones and Their Applications in Asymmetric Catalysis" Longmire, J. M. and Zhang, X. Tetrahedron Letters 1997, 38, 1725-1728.

(10) "Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by a Titanate Complex with a Chiral Tetradentate Ligand" Qiu, J., Guo, C. and Zhang, X. J. Org. Chem. 1997, 62, 2665-2668.

(11) "Highly Enantioselective Rh-Catalyzed Hydrogenations with a New Chiral 1,4-Bisphosphine Containing a Cyclic Backbone" Zhu, G., Cao, P., Jiang, Q. and Zhang, X. J. Am. Chem. Soc. 1997, 119, 1799-1800.

(12) "Asymmetric [3 + 2] Cycloaddition of 2,3-Butadienoates with Electron-Deficient Olefins Catalyzed by Novel Chiral 2,5-Dialkyl-7-phenyl-7- phosphabicyclo[2.2.1]heptanes" Zhu, G., Chen, Z., Jiang, Q., Xiao, D., Cao, P. and Zhang, X. J. Am. Chem. Soc. 1997, 119, 3836-3837.

(13) "Asymmetric hydrosilylation of ketones catalyzed by ruthenium complexes with chiral tridentate lignads" Zhu, G., Terry, M. and Zhang, X. J. Organometallic Chem. 1997, 547, 97-101.

(14) "Asymmetric Formation of Quaternary Carbon Centers Catalyzed by Novel Chiral 2,5-Dialkyl-7-phenyl-7-phosphabicyclo-[2.2.1]heptanes" Chen, Z., Zhu, G., Jiang, Q., Xiao, D., Cao, P. and Zhang, X. J. Org. Chem. 1998, 63, 5631-5635.

(15) "Highly Enantioselective Hydrogenation of Simple Ketones Catalyzed by a Rh-PennPhos Complex" Jiang, Q., Jiang, Y., Xiao, D., Cao, P. and Zhang, X. Angew. Chem. Int. Ed. 1998, 37, 1100-1103.

(16) "A New Chiral Bis(oxazolinylmethyl)amine Ligand for Ru-Catalyzed Asymmetric Transfer Hydrogenation of Ketones" Jiang, Y., Jiang, Q. and Zhang, X. J. Am. Chem. Soc. 1998, 120, 3817-3818.

(17) "Synthesis and X-ray Crystal Structures of Palladium(II) and Platinum(II) Complexes of the PCP-Type Chiral Tridentate Ligand (1R,1'R)-1,3-Bis[1-(diphenylphosphino)ethyl]benzene. Use in the Asymmetric Aldol Reaction of Methyl Isocyanoacetate and Aldehydes" Longmire, J. M. and Zhang, X. Organometallics 1998, 17, 4374-4379.

(18) "Synthesis of Novel Chiral 2,5-Dialkyl-7-azabicyclo[2.2.1] heptanes and 2,5-Dialkyl-7-thiobicyclo[2.2.1]heptanes" Xiao, D., Zhang, Z., Jiang, Q. and Zhang, X. Tetrahedron Letters 1998, 39, 5331-5334.

(19) "Highly Enantioselective Rhodium-Catalyzed Hydrogenation of Dehydroamino Acids with New Chiral Bisphosphinites" Zhu, G. and Zhang, X. J. Org. Chem. 1998, 63, 3133-3136.

(20) "Practical Syntheses of b-Amino Alcohols via Asymmetric Catalytic Hydrogenation" Zhu, G., Casalnuovo, A. L. and Zhang, X. J. Org. Chem. 1998, 63, 8100-8101.

(21) "Asymmetric Rh-Catalyzed Hydrogenation of Enamides with a Chiral 1,4-Bisphosphine Bearing Diphenylphosphino Groups" Zhu, G. and Zhang, X. J. Org. Chem. 1998, 63, 9590-9593.

(22) "Additive effects in Ir-BICP catalyzed asymmetric hydrogenation of imines" Zhu, G. and Zhang, X. Tetrahedron: Asymmetry 1998, 9, 2415-2418.

(23) "Highly Enantioselective Cyclocarbonylation of Allylic Alcohols Catalyzed by Novel Pd-1,4-bisphosphine Complexes" Cao, P. and Zhang, X. J. Am. Chem. Soc. 1999, 121, 7708-7709.

(24) "Ru-BICP-Catalyzed Asymmetric Hydrogenation of Aromatic Ketones" Cao, P. and Zhang, X. J. Org. Chem. 1999, 64, 2127-2129.

(25) "Development of New Chiral P,N Ligands and Their Application in the Cu-Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones" Hu, X., Chen, H. and Zhang, X. Angew. Chem. Int. Ed. 1999, 38, 3518-3521.

(26) "Highly Enantioselective Hydrogenation of Cyclic Enol Acetates Catalyzed by a Rh-PennPhos Complex" Jiang, Q., Xiao, D., Zhang, Z., Cao, P. and Zhang, X. Angew. Chem. Int. Ed. 1999, 38, 516-518.

(27) "Rhodium-hydroxyl bisphospholane catalyzed highly enantioselective hydrogenation of dehydroamino aicds and esters" Li, W., Zhang, Z., Xiao, D. and Zhang, X. Tetrahedron Letters 1999, 40, 6701-6704.

(28) "Synthesis of a Novel Chiral Binaphthyl Phospholane and Its Application in the Highly Enantioselective Hydrogenation of Enamides" Xiao, D., Zhang, Z. and Zhang, X. Org. Lett. 1999, 1, 1679-1681.

(29) "The First Tridentate Ligand for Catalytic Enantioselective Aza-Claisen Rearrangement of Allylic Imidates" Yutong, J., Longmire, J. M. and Xumu, Z. Tetrahedron Letters 1999, 40, 1449-1450.

(30) "Highly Enantioselective Hydrogenation of Cyclic Enamides Catalyzed by a Rh-PennPhos Catalyst" Zhang, Z., Zhu, G., Jiang, Q., Xiao, D. and Zhang, X. J. Org. Chem. 1999, 64, 1774-1775.

(31) "Highly Efficient Asymmetric Synthesis of b-Amino Acid Derivatives via Rhodium-Catalyzed Hydrogenation of b-(Acylamino)acrylate" Zhu, G., Chen, Z. and Zhang, X. J. Org. Chem. 1999, 64, 6907-6910.

(32) "The First Highly Enantioselective Rh-Catalyzed Enyne Cycloisomerization" Cao, P. and Zhang, X. Angew. Chem. Int. Ed. 2000, 39, 4104-4106.

(33) "Rh-Catalyzed Enyne Cycloisomerization" Cao, P., Wang, B. and Zhang, X. J. Am. Chem. Soc. 2000, 122, 6490-6491.

(34) "Synthesis of Chiral Hydroxyl Phospholanes from D-mannitol and Their Use in Asymmetric Catalytic Reactions" Li, W., Zhang, Z., Xiao, D. and Zhang, X. J. Org. Chem. 2000, 65, 3489-3496.

(35) "Synthesis of 3, 4-O-Isopropylidene- (3S,4S)-dihydroxy-(2R,5R)-bis(diphenylphosphino)hexane and Its Application in Rh-Catalyzed Highly Enantioselective Hydrogenation of Enamides" Li, W. and Zhang, X. J. Org. Chem. 2000, 65, 5871-5874.

(36) "Highly efficient kinetic resolution of 2-cyclohexenyl acetate in Pd-catalyzed allylic alkylation" Longmire, J., Wang, B. and Zhang, X. Tetrahedron Letters 2000, 41, 5435-5439.

(37) "An efficient Rh-catalyst system for the intramolecular [4+2] and [5+2] cycloaddition reactions" Wang, B., Cao, P. and Zhang, X. Tetrahedron Letters 2000, 41, 8041ĘC8044.

(38) "Synthesis of Chiral Bisphosphines with Tunable Bite Angles and Their Applications in Asymmetric Hydrogenation of b-Ketoesters" Zhang, Z., Qian, H., Longmire, J. and Zhang, X. J. Org. Chem. 2000, 65, 6223-6226.

(39) "Highly Enantioselective Hydrogenation of Acyclic Imines Catalyzed by Ir - f-Binaphane Complexes" Xiao, D. and Zhang, X. Angew. Chem. Int. Ed. 2001, 40, 3425-3428.

(40) "Synthesis of novel chiral binaphthyl phosphorus ligands and their applications in Rh-catalyzed asymmetric hydrogenation" Chi, Y. and Zhang, X. Tetrahedron Letters 2002, 43, 4849ĘC4852.

(41) "A practical synthesis of 2-amino-2'-hydroxy-1,1'-binaphthyl (NOBIN)" Korber, K., Tang, W., Hu, X. and Zhang, X. Tetrahedron Letters 2002, 43, 7163-7165.

(42) "Highly Enantioselective Rh-Catalyzed Intramolecular Alder-Ene Reactions for the Syntheses of Chiral Tetrahydrofurans" Lei, A., He, M., Wu, S. and Zhang, X. Angew. Chem. Int. Ed. 2002, 41, 3457-3460.

(43) "Highly Enantioselective Syntheses of Functionalized -a-Methylene-g-butyrolactones via Rh(I)-catalyzed Intramolecular Alder Ene Reaction: Application to Formal Synthesis of (+)-Pilocarpine" Lei, A., He, M. and Zhang, X. J. Am. Chem. Soc. 2002, 124, 8198-8199.

(44) "Transmetalation of Palladium Enolate and Its Application in Palladium-Catalyzed Homocoupling of Alkynes: A Room-Temperature, Highly Efficient Route To Make Diynes" Lei, A., Srivastava, M. and Zhang, X. J. Org. Chem. 2002, 67, 1969-1971.

(45) "Palladium-Catalyzed Homocoupling Reactions between Two Csp3-Csp3 Centers" Lei, A. and Zhang, X. Org. Lett. 2002, 4, 2285-2288.

(46) "A novel palladium-catalyzed homocoupling reaction initiated by transmetallation of palladium enolates" Lei, A. and Zhang, X. Tetrahedron Letters 2002, 43, 2525ĘC2528.

(47) "Highly Enantioselective Cycloisomerization of Enynes Catalyzed by Rhodium for the Preparation of Functionalized Lactams" Lei, A., Waldkirch, J. P., He, M. and Zhang, X. Angew. Chem. Int. Ed. 2002, 41, 4526-4529.

(48) "Chiral C2-Symmetric Ligands with 1,4-Dioxane Backbone Derived from Tartrates: Syntheses and Applications in Asymmetric Hydrogenation" Li, W., Waldkirch, J. P. and Zhang, X. J. Org. Chem. 2002, 67, 7618-7623.

(49) "A Novel Chiral Ferrocenyl Phosphine Ligand from Sugar: Applications in Rh-Catalyzed Asymmetric Hydrogenation Reactions" Liu, D., Li, W. and Zhang, X. Org. Lett. 2002, 4, 4471-4474.

(50) "Highly Enantioselective Ag(I)-Catalyzed [3 + 2] Cycloaddition of Azomethine Ylides" Longmire, J. M., Wang, B. and Zhang, X. J. Am. Chem. Soc. 2002, 124, 13400-13401.

(51) "A Chiral 1,2-Bisphospholane Ligand with a Novel Structural Motif: Applications in Highly Enantioselective Rh-Catalyzed Hydrogenations" Tang, W. and Zhang, X. Angew. Chem. Int. Ed. 2002, 41, 1612-1614.

(52) "An ortho-Substituted BIPHEP Ligand and Its Applications in Rh-Catalyzed Hydrogenation of Cyclic Enamides" Tang, W., Chi, Y. and Zhang, X. Org. Lett. 2002, 4, 1695-1698.

(53) "A new chiral ruthenium complex for catalytic asymmetric cyclopropanation" Tang, W., Hu, X. and Zhang, X. Tetrahedron Letters 2002, 43, 3075-3078.

(54) "Highly Efficient Synthesis of Chiral b-Amino Acid Derivatives via Asymmetric Hydrogenation" Tang, W. and Zhang, X. Org. Lett. 2002, 4, 4159-4161.

(55) "Highly Enantioselective Hydrogenation of Enol Acetates Catalyzed by Ru-TunaPhos Complexes" Wu, S., Wang, W., Tang, W., Lin, M. and Zhang, X. Org. Lett. 2002, 4, 4495-4497.

(56) "Highly Effective Chiral Ortho-Substituted BINAPO Ligands ( o-BINAPO): Applications in Ru-Catalyzed Asymmetric Hydrogenations of b-Aryl-Substituted b-(Acylamino)acrylates and b-Keto Esters" Zhou, Y.-G., Tang, W., Wang, W.-B., Li, W. and Zhang, X. J. Am. Chem. Soc. 2002, 124, 4952-4953.

(57) "Synthesis of novel BINOL-derived chiral bisphosphorus ligands and their application in catalytic asymmetric hydrogenation" Zhou, Y.-G. and Zhang, X. Chem. Commun. 2002, 1124-1125.

(58) "Asymmetric Hydrogenation of Itaconic Acid and Enol Acetate Derivatives with the Rh-TangPhos Catalyst" Tang, W., Liu, D. and Zhang, X. Org. Lett. 2003, 5, 205-207.

(59) "Highly Enantioselective Reductive Amination of Simple Aryl Ketones Catalyzed by Ir-f-Binaphane in the Presence of Titanium(IV) Isopropoxide and Iodine" Chi, Y., Zhou, Y. and Zhang, X. J. Org. Chem. 2003, 68, 4120-4122.

(60) "Rh-Catalyzed Kinetic Resolution of Enynes and Highly Enantioselective Formation of 4-Alkenyl-2,3-disubstituted Tetrahydrofurans" Lei, A., He, M. and Zhang, X. J. Am. Chem. Soc. 2003, 125, 11472-11473.

(61) "Phospholane-Oxazoline Ligands for Ir-Catalyzed Asymmetric Hydrogenation" Tang, W., Wang, W. and Zhang, X. Angew. Chem. Int. Ed. 2003, 42, 943-946.

(62) "A Bisphosphepine Ligand with Stereogenic Phosphorus Centers for the Practical Synthesis of b-Aryl-b-Amino Acids by Asymmetric Hydrogenation" Tang, W., Wang, W., Chi, Y. and Zhang, X. Angew. Chem. Int. Ed. 2003, 42, 3509-3511.

(63) "New Chiral Phosphorus Ligands for Enantioselective Hydrogenation" Tang, W. and Zhang, X. Chem. Rev. 2003, 103, 3029-3069.

(64) "Enantioselective Hydrogenation of Tetrasubstituted Olefins of Cyclic b-(Acylamino)acrylates" Tang, W., Wu, S. and Zhang, X. J. Am. Chem. Soc. 2003, 125, 9570-9571.

(65) "Novel Rhodium-Catalyzed Cycloisomerization of 1,6-Enynes with an Intramolecular Halogen Shift" Tong, X., Zhang, Z. and Zhang, X. J. Am. Chem. Soc. 2003, 125, 6370-6371.

(66) "Synthesis of a New Class of Conformationally Rigid Phosphino-oxazolines: Highly Enantioselective Ligands for Ir-Catalyzed Asymmetric Hydrogenation" Liu, D.; Tang, W.; Zhang, X. Org. Lett. 2004, 6, 513-516.

(67) "Highly Enantioselective Asymmetric Hydrogenation of a-Phthalimide Ketone: An Efficient Entry to Enantiomerically Pure Amino Alcohols" Lei, A.; Wu, S.; He, M.; Zhang, X. J. Am. Chem. Soc. 2004, 126, 1626-1627.

(68) " Novel phosphine-phosphite and phosphine-phosphinite ligands for highly enantioselective asymmetric hydrogenation" Yan, Y.; Chi, Y.; Zhang, X. Tetrahedron: Asymmetry 2004, 15, 2173-2175.

(69) " Synthesis of ortho-phenyl substituted MeO-BIPHEP ligand and its application in Rh-catalyzed asymmetric hydrogenation" Wu, S.; He, M.; Zhang, X. Tetrahedron: Asymmetry 2004, 15, 2177-2180.

(70) " Development of DIOP derivatives as efficient ligands for asymmetric hydrogenation: factors controlling the reactivities and enantioselectivities" Liu, D.; Li, W.; Zhang, X. Tetrahedron: Asymmetry 2004, 15, 2181-2184.

(71) " Synthesis of New Monodentate Spiro Phosphoramidite Ligand and Its Application in Rh-Catalyzed Asymmetric Hydrogenation Reactions" Wu, S.; Zhang, W.; Zhang, Z.; Zhang, X. Org. Lett. 2004, 6, 3565-3567.

(72) " Practical P-Chiral Phosphane Ligand for Rh-Catalyzed Asymmetric Hydrogenation" Liu, D.; Zhang, X. Eur. J. Org. Chem. 2005, 646-649.

(73) " Practical Synthesis of Enantiopure g-Amino Alcohols by Rhodium-Catalyzed Asymmetric Hydrogenation of b-Secondary-Amino Ketones" Liu, D.; Gao, W.; Wang, C.; Zhang, X. Angew. Chem. Int. Ed., 2005, 44, 1687-1689.

(74) " Enantioselective syntheses of 3,4,5-trisubstituted g-lactones: formal synthesis of (-)-blastmycinolactol" He, M.; Lei, A.; Zhang, X. Tetrahedron Lett. 2005, 46, 1823-1826.

(75) " A new class of readily available and conformationally rigid phosphino-oxazoline ligands for asymmetric catalysis" Liu, D.; Dai, Q.; Zhang, X. Tetrahedron 2005, 61, 6460-6471.

(76) " Enantioselective Hydrogenation of Allylphthalimides: An Efficient Method for the Synthesis of b-Methyl Chiral Amines" Wang, C.-J.; Sun, X.; Zhang, X. Angew. Chem. Int. Ed. 2005, 44, 4933-4935.

(77) " Highly enantioselective copper-catalyzed conjugate addition of diethylzinc to cyclic enones with spirocyclic phosphoramidite ligands" Zhang, W.; Wang, C.-J.; Gao, W.; Zhang, X. Tetrahedron Lett. 2005, 46, 6087-6090.

(78) " Cu(I)-Catalyzed Highly Exo-selective and Enantioselective [3 + 2] Cycloaddition of Azomethine Ylides with Acrylates" Gao, W.; Zhang, X.; Raghunath, M. Org. Lett. 2005, 7, 4241-4244.

(79) " Triazole-Based Monophosphines for Suzuki-Miyaura Coupling and Amination Reactions of Aryl Chlorides" Liu, D.; Gao, W.; Dai, Q.; Zhang, X. Org. Lett. 2005, 7, 4907-4910.

(80) " Ferrocenyl bis-phosphine ligands bearing sulfinyl, sulfonyl or sulfenyl groups: applications in asymmetric hydrogenation and allylic alkylation reactions" Raghunath, M.; Gao, W.; Zhang, X. Tetrahedron: Asymmetry 2005, 16, 3676-3681.

(81) " A correlation study of bisphosphine ligand bite angles with enantioselectivity in Pd-catalyzed asymmetric transformations" Raghunath, M.; Zhang, X. Tetrahedron Lett. 2005, 46, 8213-8216.

(82) " Efficient Rhodium-Catalyzed Asymmetric Hydrogenation for the Synthesis of a New Class of N-Aryl b-Amino Acid Derivatives" Dai, Q.; Yang, W.; Zhang, X. Org. Lett. 2005, 7, 5343-5345.

(83) " Chiral bisphospholane ligands (Me-ketalphos): synthesis of their Rh(I) complexes and applications in asymmetric hydrogenation" Dai, Q.; Wang, C.-J.; Zhang, X. Tetrahedron 2006, 62, 868-871.

(84) " Highly enantioselective hydrogenation of N-phthaloyl enamides" Yang, Q.; Gao, W.; Deng, J.; Zhang, X. Tetrahedron Lett. 2006, 47, 821-823.

(85) " Six-membered bis(azaphosphorinane), readily available ligand for highly enantioselective asymmetric hydrogenations" Yan, Y.; Zhang, X. Tetrahedron Lett. 2006, 47, 1567-1569.

(86) " Highly enantioselective Ru-catalyzed hydrogenation of b-keto esters using electron-donating bis(trialkylphosphine) ligand-TangPhos" Wang, C.-J.; Tao, H.; Zhang, X. Tetrahedron Lett. 2006, 47, 1901-1903.

(87) " Triazole-Based Monophosphine Ligands for Palladium-Catalyzed Cross-Coupling Reactions of Aryl Chlorides" Dai, Q.; Gao, W.; Liu, D.; Kapes, L. M.; Zhang, X. J. Org. Chem. 2006, 71, 3928-3934.

(88) " (h5-Triphenylindenyl)Ru(CO)2Cl: A New Ruthenium Catalyst for the Highly Efficient Racemization of Chiral 1-Phenylethanol at Room Temperature" Xi, Q.; Zhang, W.; Zhang, X. Synlett 2006, 945-947.

(89) " Highly Enantioselective Hydrogenation of a-Keto Esters Catalyzed by Ru-Tunephos Complexes" Wang, C.-J.; Sun, X.; Zhang, X. Synlett 2006, 1169-1172.

(90) " A Highly Enantioselective, Pd-TangPhos-Catalyzed Hydrogenation of N-Tosylimines" Yang, Q.; Shang, G.; Gao, W.; Deng, J.; Zhang, X. Angew. Chem. Int. Ed. 2006, 45, 3832-3835.

(91) " A Hybrid Phosphorus Ligand for Highly Enantioselective Asymmetric Hydroformylation" Yan, Y.; Zhang, X. J. Am. Chem. Soc. 2006, 128, 7198-7202.

(92) " Synthesis of Triphosphorous Bidentate Phosphine-Phosphoramidite Ligands and their Application in Highly Enantioselective Hydrogenation of ortho-Substituted Aryl Enamides" Zhang, W.; Zhang, X. Angew. Chem. Int. Ed. 2006, 45, 5515-5518.

(93) " Rh-Catalyzed Asymmetric Hydrogenation of a-Aryl Imino Esters: An Efficient Enantioselective Synthesis of Aryl Glycine Derivatives" Shang, G.; Yang, Q.; Zhang, X. Angew. Chem. Int. Ed. 2006, 45, 6360-6362.

(94) " Asymmetric Hydrogenation of Pyridines: Enantioselective Synthesis of Nipecotic Acid Derivatives" Lei, A.; Chen, M.; He, M.; Zhang, X. Eur. J. Org. Chem. 2006, 45, 4343-4347.